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Article

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.

Neurochemistry international - 1 Oct 2012

van Tijn Paula, Dennissen Frank J A, Gentier Romina J G, Hobo Barbara, Hermes Denise, Steinbusch Harry W M, Van Leeuwen Fred W, Fischer David F

Abstract excerpt

The mutant ubiquitin UBB(+1) is a substrate as well as an inhibitor of the ubiquitin-proteasome system (UPS) and accumulates in the neuropathological hallmarks of Alzheimer's disease (AD). A role for the UPS has been suggested in the generation of amyloid β (Aβ) plaques in AD. To investigate the effect of UBB(+1) expression on amyloid pathology in vivo, we crossed UBB(+1) transgenic mice with a transgenic line...

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Source

Identifiers

PMID: 22797007
DOI: 10.1016/j.neuint.2012.07.007

Genes

UBB

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