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Article

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2001

De Vrij F M, Sluijs J A, Gregori L, Fischer D F, Hermens W T, Goldgaber D, Verhaagen J, Van Leeuwen F W, Hol E M

Abstract excerpt

Ubiquitin-B+1 (UBB+1) is a mutant ubiquitin that accumulates in the neurones of patients with Alzheimer's disease (AD). Here we report on the biochemical and functional differences between ubiquitin and UBB+1 and the effect of the mutant protein on neuronal cells. UBB+1 lacks the capacity to ubiq...

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Identifiers

PMID: 11726544
DOI: 10.1096/fj.01-0438com

Genes

UBB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-11726544-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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