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Article

Alzheimer-associated mutant ubiquitin impairs spatial reference memory.

Physiology & behavior - 1 Feb 2011

van Tijn Paula, Hobo Barbara, Verhage Marian C, Oitzl Melly S, van Leeuwen Fred W, Fischer David F

Abstract excerpt

UBB(+1) is a mutant ubiquitin which accumulates in the hallmarks of tauopathies, including Alzheimer's disease. Transgenic mice expressing high levels of neuronal UBB(+1) exhibit moderately decreased proteasome activity and spatial reference memory deficits at 9months of age. In the present study...

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Identifiers

PMID: 21059367
DOI: 10.1016/j.physbeh.2010.11.001

Genes

UBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21059367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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