Article
Patterns of internal and external tetraethylammonium block in four homologous K+ channels.
Molecular pharmacology - 1 Aug 1991
Taglialatela M, Vandongen A M, Drewe J A, Joho R H, Brown A M, Kirsch G E
Abstract excerpt
Tetraethylammonium (TEA) is a small ion that is thought to block open K+ channels by binding either to an internal or to an external site. For this reason, it has been used to probe the ion conduction pathway or pore of K+ channel mutants and a K+ channel chimera. The results suggested that the region between transmembrane segments 5 and 6 (S5-S6 linker) was involved in the formation of both the internal and the...
Topics
- Animals
- Binding Sites
- Metabolic Clearance Rate
- Mutation
- Potassium Channels
- Quaternary Ammonium Compounds
- Rats
- Structure-Activity Relationship
- Tetraethylammonium Compounds