Article
Patterns of internal and external tetraethylammonium block in four homologous K+ channels.
Molecular pharmacology - 1 Aug 1991
Taglialatela M, Vandongen A M, Drewe J A, Joho R H, Brown A M, Kirsch G E
Abstract excerpt
Tetraethylammonium (TEA) is a small ion that is thought to block open K+ channels by binding either to an internal or to an external site. For this reason, it has been used to probe the ion conduction pathway or pore of K+ channel mutants and a K+ channel chimera. The results suggested that the region between transmembrane segments 5 and 6 (S5-S6 linker) was involved in the formation of both the internal and the...
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