Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.

Abstract excerpt

Rectification of macroscopic current through inward-rectifier K+ (Kir) channels reflects strong voltage dependence of channel block by intracellular cations such as polyamines. The voltage dependence results primarily from the movement of K+ ions across the transmembrane electric field, which accompanies the binding-unbinding of a blocker. Residues D172, E224, and E299 in IRK1 are critical for high-affinity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Membrane Potentials
• Share to Mutation
• Share to Potassium Channels, Inwardly Rectifying