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Article

Internal Mg2+ block of recombinant NMDA channels mutated within the selectivity filter and expressed in Xenopus oocytes.

The Journal of physiology - 15 Feb 1998

Kupper J, Ascher P, Neyton J

Abstract excerpt

1. The NMDA receptor channel is blocked by both external and internal Mg2+ ions, which are assumed to bind inside the channel on each side of a central barrier. We have analysed the internal Mg2+ block in recombinant NR1-NR2A NMDA receptors expressed in Xenopus oocytes. We have determined the effects of mutations of two asparagines that line the selectivity filter of the channel, one located within the NR1...

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Identifiers

PMID: 9490808
DOI: 10.1111/j.1469-7793.1998.001bu.x
PMCID: PMC2230784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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