Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores.

Neuron - 1 Sept 1993

Kirsch G E, Shieh C C, Drewe J A, Vener D F, Brown A M

Abstract excerpt

4-Aminopyridine (4AP) blocks the intracellular mouth of voltage-gated K+ channels. We identified critical regions for 4AP binding with chimeric channels in which segments of a low affinity clone (Kv2.1, IC50 = 18 mM) were replaced with those of a high affinity clone (Kv3.1, IC50 = 0.1 mM). 4AP sensitivity was not transferred with the S5-S6 linker (pore or P region). Instead, a chimera of the cytoplasmic half of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding, Competitive
Share to Chimera

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intracellular Membranes

Share to Ion Channel Gating

Share to Molecular Sequence Data

Share to Mutation

Share to Potassium Channels

Source

Identifiers

PMID: 8398143
DOI: 10.1016/0896-6273(93)90154-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores.PMID 8398143Read ↗

Mutational analysis of ion conduction and drug binding sites in the inner mouth of voltage-gated K+ channels.Semantic proximity Read ↗

Role of transmembrane segment S5 on gating of voltage-dependent K+ channels.Semantic proximity Read ↗

Comparison of H5, S6, and H5-S6 exchanges on pore properties of voltage-dependent K+ channels.Semantic proximity Read ↗

Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.Semantic proximity Read ↗

A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.Semantic proximity Read ↗

Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil?Semantic proximity Read ↗

The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.Semantic proximity Read ↗

Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating.Semantic proximity Read ↗

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.Semantic proximity Read ↗

The pore of the voltage-gated proton channel.Semantic proximity Read ↗

Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel.Semantic proximity Read ↗

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.