Article
Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channel.
The Journal of general physiology - 1 Aug 2006
Trapani Josef G, Andalib Payam, Consiglio Joseph F, Korn Stephen J
Abstract excerpt
Current magnitude in Kv2.1 potassium channels is modulated by external [K+]. In contrast to behavior expected from the change in electrochemical driving force, outward current through Kv2.1 channels becomes larger when extracellular [K+] is increased within the physiological range. The mechanism that underlies this unusual property involves the opening of Kv2.1 channels into one of two different outer vestibule...
Topics
- Algorithms
- Amino Acid Substitution
- Animals
- CHO Cells
- Cricetinae
- Cricetulus
- Humans
- Ion Channel Gating
- Lysine
- Markov Chains
- Membrane Potentials
- Mutation
- Patch-Clamp Techniques
- Potassium
- Protein Conformation
- Quaternary Ammonium Compounds
- Shab Potassium Channels
- Transfection