Article
Comparison of H5, S6, and H5-S6 exchanges on pore properties of voltage-dependent K+ channels.
The Journal of biological chemistry - 13 May 1994
Taglialatela M, Champagne M S, Drewe J A, Brown A M
Abstract excerpt
Evidence is now substantial that membrane segments besides H5 contribute to the pore of K+ channels. We found that substitution of the H5 region of Shaker B (ShB) with the corresponding sequence of NGK2 expressed channels which retained the single channel K+ conductance (gK+) of the host ShB channel. A reverse chimera with ShB H5 region transplanted into NGK2 also retained the gK+ of the host NGK2. Point...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- Ion Channel Gating
- Molecular Sequence Data
- Mutation
- Peptides
- Potassium Channel Blockers
- Potassium Channels
- Shaker Superfamily of Potassium Channels
- Tetraethylammonium