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Article

Effects of channel cytoplasmic regions on the activation mechanisms of cardiac versus skeletal muscle Na(+) channels.

Biophysical journal - 1 Dec 1999

Bennett E S

Abstract excerpt

Functional comparison of skeletal muscle (rSkM1) and cardiac (hH1) voltage-gated sodium channel isoforms expressed in Chinese hamster ovary cells showed rSkM1 half-activation (V(a)) and inactivation (V(i)) voltages 7 and 10 mV more depolarized than hH1 V(a) and V(i), respectively. Internal papain perfusion removed fast inactivation from each isoform and caused a 20-mV hyperpolarizing shift in hH1 V(a), with an...

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Identifiers

PMID: 10585922
DOI: 10.1016/S0006-3495(99)77131-6
PMCID: PMC1300571

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Source receipt: pubmed, retrieved 7 Sept 2026.

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