Article
Mutational analysis of ion conduction and drug binding sites in the inner mouth of voltage-gated K+ channels.
Biophysical journal - 1 Dec 1994
Shieh C C, Kirsch G E
Abstract excerpt
Pore properties that distinguish two cloned, voltage-gated K+ channels, Kv2.1 and Kv3.1, include single-channel conductance, block by external and internal tetraethylammonium, and block by 4-aminopyridine. To define the inner mouth of voltage-gated K+ channels, segmental exchanges and point mutat...
Topics
- 4-Aminopyridine
- Amino Acid Sequence
- Animals
- Binding Sites
- Biophysical Phenomena
- Biophysics
- Delayed Rectifier Potassium Channels
- Electric Conductivity
- Female
- In Vitro Techniques
- Molecular Sequence Data
- Molecular Structure
- Mutagenesis, Site-Directed
- Mutation
- Neuropeptides
- Point Mutation
- Potassium Channel Blockers
- Potassium Channels