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Article

Mutational analysis of ion conduction and drug binding sites in the inner mouth of voltage-gated K+ channels.

Biophysical journal - 1 Dec 1994

Shieh C C, Kirsch G E

Abstract excerpt

Pore properties that distinguish two cloned, voltage-gated K+ channels, Kv2.1 and Kv3.1, include single-channel conductance, block by external and internal tetraethylammonium, and block by 4-aminopyridine. To define the inner mouth of voltage-gated K+ channels, segmental exchanges and point mutations of nonconserved residues were used. Transplanting the cytoplasmic half of either transmembrane segments S5 or S6...

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Identifiers

PMID: 7696472
DOI: 10.1016/S0006-3495(94)80718-0
PMCID: PMC1225616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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