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Article

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.

The American journal of psychiatry - 1 Apr 2002

Malhotra Anil K, Kestler Lisa J, Mazzanti Chiara, Bates John A, Goldberg Terry, Goldman David

Abstract excerpt

OBJECTIVE: In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype. METHOD:...

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Source

Identifiers

PMID: 11925305
DOI: 10.1176/appi.ajp.159.4.652

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.PMID 11925305Read ↗

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