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Article

Large-scale nucleotide optimization of simian immunodeficiency virus reduces its capacity to stimulate type I interferon in vitro.

Journal of virology - 1 Apr 2014

Vabret Nicolas, Bailly-Bechet Marc, Lepelley Alice, Najburg Valérie, Schwartz Olivier, Verrier Bernard, Tangy Frédéric

Abstract excerpt

UNLABELLED: Lentiviral RNA genomes present a strong bias in their nucleotide composition with extremely high frequencies of A nucleotide in human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV). Based on the observation that human optimization of RNA virus gene fragments may abolish their ability to stimulate the type I interferon (IFN-I) response, we identified the most biased...

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Source

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Identifiers

PMID: 24478441
DOI: 10.1128/JVI.03223-13
PMCID: PMC3993766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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