Article
HIV-1 evolution: frustrating therapies, but disclosing molecular mechanisms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jun 2010
Das Atze T, Berkhout Ben
Abstract excerpt
Replication of HIV-1 under selective pressure frequently results in the evolution of virus variants that replicate more efficiently under the applied conditions. For example, in patients on antiretroviral therapy, such evolution can result in variants that are resistant to the HIV-1 inhibitors, thus frustrating the therapy. On the other hand, virus evolution can help us to understand the molecular mechanisms that...
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