Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 tolerates changes in A-count in a small segment of the pol gene.

Retrovirology - 5 Sept 2017

Klaver Bep, van der Velden Yme, van Hemert Formijn, van der Kuyl Antoinette C, Berkhout Ben

Abstract excerpt

BACKGROUND: The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not been systematically manipulated. The reason for this reservation is the likelihood that known and unknown sequence motifs will be affected by such a massive mutational approach, thus resulting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to Genes, pol
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Reverse Transcriptase

Share to Silent Mutation

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 28870251
DOI: 10.1186/s12977-017-0367-0
PMCID: PMC5583962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 tolerates changes in A-count in a small segment of the pol gene.PMID 28870251Read ↗

The A-nucleotide preference of HIV-1 in the context of its structured RNA genome.Semantic proximity Read ↗

The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virusSemantic proximity Read ↗

Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.Semantic proximity Read ↗

Biased Mutation and Selection in RNA Viruses.Semantic proximity Read ↗

In-depth investigation of the point mutation pattern of HIV-1.Semantic proximity Read ↗

Large-scale nucleotide optimization of simian immunodeficiency virus reduces its capacity to stimulate type I interferon in vitro.Semantic proximity Read ↗

Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol ProteinsSemantic proximity Read ↗

High-throughput profiling of point mutations across the HIV-1 genomeSemantic proximity Read ↗

The Disassociation of A3G-Related HIV-1 cDNA G-to-A Hypermutation to Viral Infectivity.Semantic proximity Read ↗

Spontaneous Mutations in HIV-1 Gag, protease, RT p66 in the first replication cycle and how they appear: Insights from an <i>in vitro</i> BSL2 assay on mutation rates and typesSemantic proximity Read ↗

Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types.Semantic proximity Read ↗

Implications of HIV RNA structure for recombination, speciation, and the neutralism-selectionism controversy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.