HIV-1 tolerates changes in A-count in a small segment of the pol gene.

doi:10.1186/s12977-017-0367-0

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Article

HIV-1 tolerates changes in A-count in a small segment of the pol gene.

Retrovirology - 5 Sept 2017

Klaver Bep, van der Velden Yme, van Hemert Formijn, van der Kuyl Antoinette C, Berkhout Ben

Abstract excerpt

BACKGROUND: The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not been systematically manipulated. The reason for this reservation is the likelihood that known and unknown sequence motifs will be affected by such a massive mutational approach, thus resulting...

Topics

AT Rich Sequence
Base Composition
Cells, Cultured
Evolution, Molecular
Genes, pol
Genetic Variation
HEK293 Cells
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Phylogeny
RNA, Viral
Silent Mutation
Virus Replication

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Identifiers

PMID: 28870251
DOI: 10.1186/s12977-017-0367-0
PMCID: PMC5583962

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