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Article

Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.

The Journal of biological chemistry - 18 Jun 2004

Smith Robert A, Anderson Donovan J, Preston Bradley D

Abstract excerpt

DNA and RNA polymerases share a core architecture composed of three structurally conserved motifs: A, B, and C. Although the amino acid sequences of these motifs are highly conserved between closely related organisms, variation across broader evolutionary distances suggests that only a few residues in each motif are indispensable for polymerase function. To test this, we constructed libraries of human...

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Identifiers

PMID: 15014075
DOI: 10.1074/jbc.M314038200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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