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Article

Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.

The Biochemical journal - 1 Jan 2009

Barak Dov, Ordentlich Arie, Stein Dana, Yu Qian-Sheng, Greig Nigel H, Shafferman Avigdor

Abstract excerpt

The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer's disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Both steps of the HuAChE carbamylation...

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Identifiers

PMID: 18729824
DOI: 10.1042/BJ20081276
PMCID: PMC2949283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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