Article
Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.
Chemico-biological interactions - 15 Dec 2005
Barak Dov, Ordentlich Arie, Kaplan Dana, Kronman Chanoch, Velan Baruch, Shafferman Avigdor
Abstract excerpt
Determination of the 3D-structure of acetylcholinesterase (AChE) of Torpedo californica over a decade ago, and more recently that of human enzyme together with extensive targeted mutagenesis of the mammalian AChEs led to a fine mapping of the multiple functional domains within the active center of the enzyme. Many of the contributions of this active center architecture to accommodation of noncovalent ligands...
Topics
- Acetylcholinesterase
- Acylation
- Alzheimer Disease
- Anions
- Binding Sites
- Cations
- Cholinesterase Inhibitors
- Humans
- Mutation
- Oxygen