Article
Defining nicotinic agonist binding surfaces through photoaffinity labeling.
Biochemistry - 31 Jul 2007
Tomizawa Motohiro, Maltby David, Medzihradszky Katalin F, Zhang Nanjing, Durkin Kathleen A, Presley Jack, Talley Todd T, Taylor Palmer, Burlingame Alma L, Casida John E
Abstract excerpt
Nicotinic acetylcholine (ACh) receptor (nAChR) agonists are potential therapeutic agents for neurological dysfunction. In the present study, the homopentameric mollusk ACh binding protein (AChBP), used as a surrogate for the extracellular ligand-binding domain of the nAChR, was specifically derivatized by the highly potent agonist azidoepibatidine (AzEPI) prepared as a photoaffinity probe and radioligand. One...
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