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Article

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.

European journal of biochemistry - 1 Nov 2003

Saxena Ashima, Fedorko James M, Vinayaka C R, Medhekar Rohit, Radić Zoran, Taylor Palmer, Lockridge Oksana, Doctor Bhupendra P

Abstract excerpt

E2020 (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (AChE) inhibitor that was approved for the treatment of Alzheimer's disease in the United States. Structure-activity studies of this class of inhibitors have indicated that both the benzoyl containing functionality and the N-benzylpiperidine moiety are the key features for binding and...

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Source

Identifiers

PMID: 14622273
DOI: 10.1046/j.1432-1033.2003.03837.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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