Article
Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.
Chemico-biological interactions - 6 Sept 2010
Küçükkilinç Tuba, Cochran Rory, Kalisiak Jaroslaw, Garcia Edzna, Valle Anne, Amitai Gabi, Radić Zoran, Taylor Palmer
Abstract excerpt
Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have been recently considered for treatment of OP poisoning as catalytic bioscavengers. In this study wild type human AChE and human AChE with residue mutations D134H, D134H_E202Q and D134H_F338A were...
Topics
- Acetylcholinesterase
- Cell Line
- Cholinesterase Inhibitors
- Cholinesterase Reactivators
- Enzyme Activation
- Humans
- Mutation
- Organophosphorus Compounds
- Oximes
- Polymorphism, Single Nucleotide