Article
Probing the peripheral site of human butyrylcholinesterase.
Biochemistry - 11 Sept 2012
Macdonald Ian R, Martin Earl, Rosenberry Terrone L, Darvesh Sultan
Abstract excerpt
Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. For both enzymes, hydrolysis takes place near the bottom of a 20 Å deep active site gorge. A number of amino acid residues within the gorge have been identified as important in facilitating efficient catalysis and...
Topics
- Binding, Competitive
- Butyrylcholinesterase
- Catalytic Domain
- Cholinesterase Inhibitors
- Humans
- Models, Molecular
- Mutation