Article
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.
Chemico-biological interactions - 15 Dec 2005
Ordentlich Arie, Barak Dov, Sod-Moriah Gali, Kaplan Dana, Mizrahi Dana, Segall Yoffi, Kronman Chanoch, Karton Yishai, Lazar Arie, Marcus Dino, Velan Baruch, Shafferman Avigdor
Abstract excerpt
The reactivity of human acetylcholinesterase (HuAChE) toward the chemical warfare agent VX [O-ethyl S-[2-(diisopropylamino)ethyl] methyl-phosphonothioate] and its stereoselectivity toward the P(S)-enantiomer were investigated by examining the reactivity of HuAChE and its mutant derivatives toward purified enantiomers of VX and its noncharged isostere nc-VX [O-ethyl S-(3-isopropyl-4-methyl-pentyl)...
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