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Article

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.

Molecular and cellular biology - 1 Jun 2003

Mohan William S, Scheer Elisabeth, Wendling Olivia, Metzger Daniel, Tora Làszlò

Abstract excerpt

TAF10 (formerly TAF(II)30), is a component of TFIID and the TATA box-binding protein (TBP)-free TAF-containing complexes (TFTC/PCAF/STAGA). To investigate the physiological function of TAF10, we disrupted its gene in mice by using a Cre recombinase/LoxP strategy. Interestingly, no TAF10(-/-) animals were born from intercrosses of TAF10(+/-) mice, indicating that TAF10 is required for embryogenesis. TAF10(-/-)...

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Source

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Identifiers

PMID: 12773572
DOI: 10.1128/MCB.23.12.4307-4318.2003
PMCID: PMC156135

Genes

TAF10
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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