Article
Generation of a mouse model for a conditional inactivation of Gtf2i allele.
Genesis (New York, N.Y. : 2000) - 1 Jul 2016
Enkhmandakh Badam, Stoddard Chris, Mack Kris, He Wei, Kaback Deb, Yee Siu-Pok, Bayarsaihan Dashzeveg
Abstract excerpt
The multifunctional transcription factor TFII-I encoded by the Gtf2i gene is expressed at the two-cell stage, inner cell mass, trophectoderm, and early gastrula stages of the mouse embryo. In embryonic stem cells, TFII-I colocalizes with bivalent domains and depletion of Gtf2i causes embryonic lethality, neural tube closure, and craniofacial defects. To gain insight into the function of TFII-I during late...
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