Article
Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.
Cancer immunology, immunotherapy : CII - 1 Mar 2009
Overes Ingrid M, Levenga T Henriëtte, Vos Johanna C M, van Horssen-Zoetbrood Agnes, van der Voort Robbert, De Mulder Pieter H, de Witte Theo M, Dolstra Harry
Abstract excerpt
CD8(+) T cells recognizing minor histocompatibility antigens (MiHA) on solid tumor cells may mediate effective graft-versus-tumor (GVT) reactivity after allogeneic stem cell transplantation (SCT). Previously, we identified LRH-1 as a hematopoietic-restricted MiHA encoded by the P2X5 gene. Here, we report that LRH-1 is aberrantly expressed on solid tumor cells. P2X5 mRNA expression is demonstrated in a significant...
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