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Article

The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival

1 Jan 2011

Abstract excerpt

B7-H4 is one of the most recently identified members of B7 superfamily of costimulatory molecules serving as an inhibitory modulator of T-cell response. B7-H4 is broadly expressed in human peripheral tissues and inducibly expressed in immune cells. The expression of B7-H4 has been observed in various types of human cancer tissues, and its soluble form has been detected in blood samples from cancer patients....

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PMID: 22013483
DOI: 10.1155/2011/695834

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