Article
Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family
1 Nov 2003
Abstract excerpt
B7-H4 is a recently identified B7 family member that negatively regulates T cell immunity by the inhibition of T cell proliferation, cytokine production, and cell cycle progression. In this study, we report that the genomic DNA of human B7-H4 is mapped on chromosome 1 comprised of six exons and five introns spanning 66 kb, of which exon 6 is used for alternative splicing to generate two different transcripts....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.