Article

The tumor necrosis superfamily member 4-1BBL expressed by tumor cells prevents exhaustion of CD8 T cells in a humanized mouse model of papillary renal cell carcinoma

2025-07-30

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> 4-1BB (CD137), a member of the TNF receptor superfamily, is a critical co-stimulatory receptor for CD8⁺ T cell activation and regulatory T cell (Treg) expansion. While its ligand 4-1BBL is typically expressed by professional antigen-presenting cells, several carcinomas also express 4-1BBL, though its function in the tumor microenvironment remains poorly defined. <h4>Methods</...

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Literature Corpus work: f4948842-d53d-593a-bb3e-7f69a3abeddf
DOI: 10.1101/2025.07.25.666825

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