Article
CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expression.
Blood - 15 Oct 2004
Dörrschuck Andreas, Schmidt Andrea, Schnürer Elke, Glückmann Matthias, Albrecht Christian, Wölfel Catherine, Lennerz Volker, Lifke Alexander, Di Natale Carmela, Ranieri Elena, Gesualdo Loreto, Huber Christoph, Karas Michael, Wölfel Thomas, Herr Wolfgang
Abstract excerpt
Allogeneic hematopoietic stem cell transplantation can induce considerable tumor remissions in metastatic renal-cell carcinoma (RCC) patients. The precise effector mechanisms mediating these graft-versus-tumor reactions are unknown. We studied RCC-directed CD8(+) T-cell responses in blood lymphocytes of healthy individuals matched with established RCC cell lines for HLA-class I. In 21 of 22 allogeneic mixed...
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