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Article

NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

2020-09-07

Abstract excerpt

<h4>ABSTRACT</h4> Downregulation of major histocompatibility complex I (MHC-I) on tumor cells is a primary means of immune evasion by many types of cancer. Additionally, MHC-I proteins are a primary target of immune-mediated transplant rejection. Transmissible tumors that overcome allograft rejection mechanisms and evade anti-tumor immunity have killed thousands of wild Tasmanian devils ( Sarcophilus harrisii )....

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Identifiers and source

Literature Corpus work
5a0380bf-8fdf-509c-ae8b-190ee348e587
DOI
10.1101/2020.09.06.274720
Open publication

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