The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

Abstract excerpt

<h4>SUMMARY</h4> While CD19- and BCMA-directed immunotherapies have improved outcomes for B-lymphoid and plasma cell malignancies, frequent relapses with antigen loss/downregulation highlight the need for new targets. Here, using transcriptomic datasets and newly-developed monoclonal antibodies, we show that P2RX5 , long considered a pseudogene in humans, encodes a stable protein in 80% of individuals of African...

Topics

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• Acute Lymphoblastic Leukemia research
• Antigens, CD19
• Binding Sites
• Epitopes
• Heterogeneous-Nuclear Ribonucleoproteins
• Leukemia, B-Cell
• Mutation
• Polypyrimidine Tract-Binding Protein

Identifiers and source

Literature Corpus work

735d49fb-68a9-547d-ae66-9aafb6e5c7b3

DOI

10.64898/2026.01.14.698748