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Article

A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia.

The Journal of clinical investigation - 1 Dec 2005

de Rijke Björn, van Horssen-Zoetbrood Agnes, Beekman Jeffrey M, Otterud Britt, Maas Frans, Woestenenk Rob, Kester Michel, Leppert Mark, Schattenberg Anton V, de Witte Theo, van de Wiel-van Kemenade Elly, Dolstra Harry

Abstract excerpt

Minor histocompatibility antigens (mHAgs) constitute the targets of the graft-versus-leukemia response after HLA-identical allogeneic stem cell transplantation. Here, we have used genetic linkage analysis to identify a novel mHAg, designated lymphoid-restricted histocompatibility antigen-1 (LRH-1), which is encoded by the P2X5 gene and elicited an allogeneic CTL response in a patient with chronic myeloid leukemia...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to HLA-B7 Antigen

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Source

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Identifiers

PMID: 16322791
DOI: 10.1172/JCI24832
PMCID: PMC1297240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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