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Article

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

15 Aug 1991

Abstract excerpt

The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic mice that overexpress BCL2 display extended survival of resting B cells. In this study we use a monospecific anti-human BCL2 antibody to define the distribution of BCL2 protein within organized tissues. BCL2 is...

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PMID: 1871110
DOI: 10.1073/pnas.88.16.6961

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