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Article

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.

Cell - 22 Oct 1993

Veis D J, Sorenson C M, Shutter J R, Korsmeyer S J

Abstract excerpt

bcl-2-/-mice complete embryonic development, but display growth retardation and early mortality postnatally. Hematopoiesis including lymphocyte differentiation is initially normal, but thymus and spleen undergo massive apoptotic involution. Thymocytes require an apoptotic signal to manifest accel...

Topics

Animals
Apoptosis
Dexamethasone
Disease Models, Animal
Hair
Hematopoiesis
Hypopigmentation
Lymphocytes
Lymphoid Tissue
Mice
Mice, Mutant Strains
Phenotype
Polycystic Kidney Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Spleen

Thymus Gland

Source

Identifiers

PMID: 8402909
DOI: 10.1016/0092-8674(93)80065-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8402909-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.PMID 8402909Read ↗

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