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BCL-2 family isoforms in apoptosis and cancer

21 Feb 2019

Abstract excerpt

The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified. The members of the Bcl-2 family are designated as such due to their BCL-2 homology (BH) domains and involvement in apoptosis regulation. The BH domains facilitate the family members' interactions...

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PMID: 30792387
DOI: 10.1038/s41419-019-1407-6

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