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Article

Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance

1 Nov 1995

Abstract excerpt

In essentially all tissues that have self-renewal capacity, there exists a delicate balance between cell production by mitogenesis and cell loss due to programmed cell death (PCD), which maintains total cell numbers within physiologically appropriate ranges. Genetic alterations that either dysregulate the cell division process, resulting in faster cell proliferation, or that affect physiological cell death...

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PMID: 8547403
DOI: 10.1097/00001622-199511000-00012

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