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The BCL-2 protein family: from discovery to drug development

9 Apr 2025

Abstract excerpt

The landmark discovery of the BCL-2 gene and then its function marked the identification of inhibition of apoptotic cell death as a crucial novel mechanism driving cancer development and launched the quest to discover the molecular control of apoptosis. This work culminated in the generation of specific inhibitors that are now in clinical use, saving and improving tens of thousands of lives annually. Here, some...

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PMID: 40204952
DOI: 10.1038/s41418-025-01481-z

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