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BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death

15 Dec 2007

Abstract excerpt

Apoptosis is a morphologically distinct form of programmed cell death essential for normal development and tissue homeostasis. Aberrant regulation of this pathway is linked to multiple human diseases, including cancer, autoimmunity, neurodegenerative disorders, and diabetes. The BCL-2 family of proteins constitutes a critical control point in apoptosis residing immediately upstream of irreversible cellular...

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PMID: 18094405
DOI: 10.1158/1078-0432.ccr-07-1598

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