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Article

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1 Apr 1995

Abstract excerpt

The control of cell survival is of central importance in tissues with high cell turnover such as the lymphoid system, and its disruption may be a critical step in tumorigenesis. Genes homologous to bcl-2, the oncogene implicated in human follicular lymphoma, play a key role in regulating physiologic cell death (apoptosis). Bcl-2 and its relatives bcl-x and bax encode intracellular membrane-bound proteins that...

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PMID: 7612233
DOI: 10.1146/annurev.iy.13.040195.002501

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