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Article

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

Cancer research - 1 Apr 1999

Cory S, Vaux D L, Strasser A, Harris A W, Adams J M

Abstract excerpt

The chromosome translocations typifying Burkitt's lymphoma and follicular lymphoma deregulate very different oncogenes, myc and bcl-2. Transgenic mouse models have illuminated how each contributes to lymphomagenesis. Constitutive myc expression provokes sustained cell proliferation and retards differentiation. However, the resulting expansion in cell number is self-limiting, because the cells remain dependent on...

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Source

Identifiers

PMID: 10197581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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