Article
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.
EMBO reports - 1 Dec 2000
Klochendler-Yeivin A, Fiette L, Barra J, Muchardt C, Babinet C, Yaniv M
Abstract excerpt
The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation, were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo, we inactivated the murine SNF5/INI1 gene, a common subunit of...
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