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Article

Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.

The Journal of clinical investigation - 1 Sept 2009

Guo Jun, Massaeli Hamid, Xu Jianmin, Jia Zongchao, Wigle Jeffrey T, Mesaeli Nasrin, Zhang Shetuan

Abstract excerpt

Although the modulation of ion channel gating by hormones and drugs has been extensively studied, much less is known about how cell surface ion channel expression levels are regulated. Here, we demonstrate that the cell surface density of both the heterologously expressed K+ channel encoded by the human ether-a-go-go-related gene (HERG) and its native counterpart, the rapidly activating delayed rectifier K+...

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Identifiers

PMID: 19726881
DOI: 10.1172/JCI39027
PMCID: PMC2735921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.PMID 19726881Read ↗

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