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Article

Caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains.

Molecular pharmacology - 1 Mar 2008

McEwen Dyke P, Li Qiuju, Jackson Sajida, Jenkins Paul M, Martens Jeffrey R

Abstract excerpt

The targeting of ion channels to cholesterol-rich membrane microdomains has emerged as a novel mechanism of ion channel localization. Previously, we reported that Kv1.5, a prominent cardiovascular K(+) channel alpha-subunit, localizes to caveolar microdomains. However, the mechanisms regulating Kv1.5 targeting and the functional significance of this localization are largely unknown. In this study, we demonstrate...

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Identifiers

PMID: 18045854
DOI: 10.1124/mol.107.042093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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