Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endocytic control of ion channel density as a target for cardiovascular disease.

The Journal of clinical investigation - 1 Sept 2009

Robertson Gail A

Abstract excerpt

Ion channels encoded by the human ether-a-go-go-related gene (HERG) give rise to the rapidly activating delayed rectifier K+ current (IKr), the perturbation of which causes ventricular arrhythmias associated with inherited and acquired long QT syndrome. Electrolyte imbalances, such as reduced serum K+ levels (hypokalemia), also trigger these potentially fatal arrhythmias. In this issue of the JCI, Guo et al....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to ERG1 Potassium Channel
Share to Ether-A-Go-Go Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypokalemia

Share to Ion Channels

Share to Models, Cardiovascular

Share to Small Ubiquitin-Related Modifier Proteins

Share to TRPM Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 19726880
DOI: 10.1172/JCI40427
PMCID: PMC2735932

Genes

TRPM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endocytic control of ion channel density as a target for cardiovascular disease.PMID 19726880Read ↗

Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.Semantic proximity Read ↗

Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.Semantic proximity Read ↗

hERG K(+) channels: structure, function, and clinical significance.Semantic proximity Read ↗

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.Semantic proximity Read ↗

Biology of cardiac arrhythmias: ion channel protein trafficking.Semantic proximity Read ↗

Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.Semantic proximity Read ↗

The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.Semantic proximity Read ↗

Trafficking and functional expression of cardiac Na+ channels.Semantic proximity Read ↗

Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome.Semantic proximity Read ↗

A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.