Article
Biology of cardiac arrhythmias: ion channel protein trafficking.
Circulation research - 11 Jun 2004
Delisle Brian P, Anson Blake D, Rajamani Sridharan, January Craig T
Abstract excerpt
The mechanisms underlying normal and abnormal cardiac rhythms are complex and incompletely understood. Through the study of uncommon inheritable arrhythmia syndromes, including the long QT and Brugada syndromes, new insights are emerging. At the cellular and tissue levels, we now recognize that ion channel current is the sum of biophysical (gating, permeation), biochemical (phosphorylation, etc), and biogenic...
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