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Article

hERG K(+) channels: structure, function, and clinical significance.

Physiological reviews - 1 Jul 2012

Vandenberg Jamie I, Perry Matthew D, Perrin Mark J, Mann Stefan A, Ke Ying, Hill Adam P

Abstract excerpt

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines. However, it is the role that Kv11.1 channels play in the heart that has been best characterized, for two main reasons. First, it is the...

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Identifiers

PMID: 22988594
DOI: 10.1152/physrev.00036.2011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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