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Article

Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems.

Molecular biology of the cell - 1 Nov 2006

Tutor Antonio S, Delpón Eva, Caballero Ricardo, Gómez Ricardo, Núñez Lucía, Vaquero Miguel, Tamargo Juan, Mayor Federico, Penela Petronila

Abstract excerpt

We identify a new mechanism for the beta(1)-adrenergic receptor (beta(1)AR)-mediated regulation of human ether-a-go-go-related gene (HERG) potassium channel (Kv11.1). We find that the previously reported modulatory interaction between Kv11.1 channels and 14-3-3epsilon proteins is competed by wild type beta(1)AR by means of a novel interaction between this receptor and 14-3-3epsilon. The association between...

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Identifiers

PMID: 16914520
DOI: 10.1091/mbc.e06-05-0422
PMCID: PMC1635398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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