Article
Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 May 2008
Mohapatra Durga P, Siino Dominic F, Trimmer James S
Abstract excerpt
Voltage-gated potassium (Kv) channels comprise four transmembrane alpha subunits, often associated with cytoplasmic beta subunits that impact channel expression and function. Here, we show that cell surface expression, voltage-dependent activation gating, and phosphorylation-dependent modulation of Kv2.1 are regulated by cytoplasmic N/C interaction within the alpha subunit. Kv2.1 surface expression is greatly...
Topics
- Amino Acid Motifs
- Animals
- Cell Line
- Cell Membrane
- Chlorocebus aethiops
- Cytoplasm
- Electrophysiology
- Humans
- Intracellular Membranes
- Ion Channel Gating
- Mutation
- Phosphorylation
- Protein Structure, Tertiary
- Protein Transport