Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse ERG K(+) channel clones reveal differences in protein trafficking and function.

Journal of the American Heart Association - 11 Dec 2014

Lin Eric C, Moungey Brooke M, Lim Evi, Concannon Sarah P, Anderson Corey L, Kyle John W, Makielski Jonathan C, Balijepalli Sadguna Y, January Craig T

Abstract excerpt

BACKGROUND: The mouse ether-a-go-go-related gene 1a (mERG1a, mKCNH2) encodes mERG K(+) channels in mouse cardiomyocytes. The mERG channels and their human analogue, hERG channels, conduct IKr. Mutations in hERG channels reduce IKr to cause congenital long-QT syndrome type 2, mostly by decreasing surface membrane expression of trafficking-deficient channels. Three cDNA sequences were originally reported for mERG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to ERG1 Potassium Channel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ether-A-Go-Go Potassium Channels

Share to Ion Channel Gating

Share to Long QT Syndrome

Share to Membrane Potentials

Share to Mice, 129 Strain

Share to Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 25497881
DOI: 10.1161/JAHA.114.001491
PMCID: PMC4338741

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse ERG K(+) channel clones reveal differences in protein trafficking and function.PMID 25497881Read ↗

Functional Analysis of a Mouse Brain Elk-Type K+ChannelSemantic proximity Read ↗

HERG trafficking and pharmacological rescue of LQTS-2 mutant channels.Semantic proximity Read ↗

Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear.Semantic proximity Read ↗

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking.Semantic proximity Read ↗

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts.Semantic proximity Read ↗

Dual Dysfunction of Kir2.1 Underlies Conduction and Excitation-Contraction Coupling Defects Promoting Arrhythmias in a Mouse Model of Andersen-Tawil Syndrome Type 1Semantic proximity Read ↗

Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes.Semantic proximity Read ↗

The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.Semantic proximity Read ↗

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.Semantic proximity Read ↗

Arrhythmia phenotype in mouse models of human long QT.Semantic proximity Read ↗

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1.Semantic proximity Read ↗

A Novel KCNH2 S981fs Mutation Identified by Whole-Exome Sequencing Is Associated with Type 2 Long QT Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.